Glucose 6 Phosphate Dehydrogenase ist ein Gen, das durch das Symbol G6PD kodiert wird. Im Allgemeinen auch bezeichnet als: Glucose-6-phosphate 1-dehydrogenase; G6PD. Glucose 6 Phosphate Dehydrogenase hat eine Masse von 59.26kDa, eine Aminosäurelänge von 515, und ist an Anemia, non-spherocytic hemolytic, due to G6PD deficiency beteiligt.
Wir bieten 13 antikörper gegen Glucose 6 Phosphate Dehydrogenase, aufgewachsen in Kaninchen, Maus und Ziege, welche geeignet sind für WB, IHC, ELISA, ICC/IF, IP and Dot mit Proben abgeleitet von Human, Maus, Ratte und S. cerevisiae.
Gen- und Proteininformationen
UniProt Zusammenfassung
Cytosolic glucose-6-phosphate dehydrogenase that catalyzes the first and rate-limiting step of the oxidative branch within the pentose phosphate pathway/shunt, an alternative route to glycolysis for the dissimilation of carbohydrates and a major source of reducing power and metabolic intermediates for fatty acid and nucleic acid biosynthetic processes.
Entrez Zusammenfassung
This gene encodes glucose-6-phosphate dehydrogenase. This protein is a cytosolic enzyme encoded by a housekeeping X-linked gene whose main function is to produce NADPH, a key electron donor in the defense against oxidizing agents and in reductive biosynthetic reactions. G6PD is remarkable for its genetic diversity. Many variants of G6PD, mostly produced from missense mutations, have been described with wide ranging levels of enzyme activity and associated clinical symptoms. G6PD deficiency may cause neonatal jaundice, acute hemolysis, or severe chronic non-spherocytic hemolytic anemia. Two transcript variants encoding different isoforms have been found for this gene.
Gewebespezifität
Isoform Long is found in lymphoblasts, granulocytes and sperm.
Rolle bei Krankheiten
Anemia, non-spherocytic hemolytic, due to G6PD deficiency: A disease characterized by G6PD deficiency, acute hemolytic anemia, fatigue, back pain, and jaundice. In most patients, the disease is triggered by an exogenous agent, such as some drugs, food, or infection. Increased unconjugated bilirubin, lactate dehydrogenase, and reticulocytosis are markers of the disorder. Although G6PD deficiency can be life-threatening, most patients are asymptomatic throughout their life.
Sequenzähnlichkeiten
Belongs to the glucose-6-phosphate dehydrogenase family.
Posttranslationale Modifikation
Acetylated by ELP3 at Lys-403; acetylation inhibits its homodimerization and enzyme activity. Deacetylated by SIRT2 at Lys-403; deacetylation stimulates its enzyme activity.
Zellort
Cytoplasm > Cytosol. Membrane.
