Glutamate Receptor 1 (AMPA subtype) ist ein Gen, das durch das Symbol GRIA1 kodiert wird. Im Allgemeinen auch bezeichnet als: Glutamate receptor 1; GluR-1; AMPA-selective glutamate receptor 1; GluR-A; GluR-K1; Glutamate receptor ionotropic, AMPA 1; GluA1; GRIA1; GLUH1; GLUR1. Glutamate Receptor 1 (AMPA subtype) hat eine Masse von 101.51kDa und eine Aminosäurelänge von 906.
Wir bieten 29 antikörper gegen Glutamate Receptor 1 (AMPA subtype), aufgewachsen in Kaninchen, Maus und Ziege, welche geeignet sind für WB, IHC, ELISA, ICC/IF and IP mit Proben abgeleitet von Human, Maus, Ratte, Affe, Huhn, Hund und Hamster.
Gen- und Proteininformationen
UniProt Zusammenfassung
Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.
Entrez Zusammenfassung
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes with multiple subunits, each possessing transmembrane regions, and all arranged to form a ligand-gated ion channel. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. This gene belongs to a family of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Gewebespezifität
Widely expressed in brain.
Sequenzähnlichkeiten
Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIA1 subfamily.
Posttranslationale Modifikation
Palmitoylated. Depalmitoylated upon glutamate stimulation. Cys-603 palmitoylation leads to Golgi retention and decreased cell surface expression. In contrast, Cys-829 palmitoylation does not affect cell surface expression but regulates stimulation-dependent endocytosis (By similarity).
Zellort
Cell membrane. Endoplasmic reticulum membrane. Cell junction > Synapse > Postsynaptic cell membrane. Cell junction > Synapse > Postsynaptic density membrane. Cell projection > Dendrite. Cell projection > Dendritic spine. Early endosome membrane. Recycling endosome membrane.
Interaction with CACNG2, CNIH2 and CNIH3 promotes cell surface expression. Colocalizes with PDLIM4 in early endosomes. Displays a somatodendritic localization and is excluded from axons in neurons (By similarity). Localized to cone photoreceptor pedicles (By similarity).
