Heme Oxygenase 1 ist ein Gen, das durch das Symbol HMOX1 kodiert wird. Im Allgemeinen auch bezeichnet als: HO-1; HMOX1; HO; HO1. Heme Oxygenase 1 hat eine Masse von 32.82kDa, eine Aminosäurelänge von 288, und ist an Heme oxygenase 1 deficiency beteiligt.
Wir bieten 15 antikörper gegen Heme Oxygenase 1, aufgewachsen in Kaninchen, Maus und Ziege, welche geeignet sind für WB, IHC, ELISA, ICC/IF and IP mit Proben abgeleitet von Human, Maus, Ratte, Rind, Schwein, Kaninchen, Affe, Hund, Meerschweinchen und Hamster.
Gen- und Proteininformationen
UniProt Zusammenfassung
Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Exhibits cytoprotective effects since excess of free heme sensitizes cells to undergo apoptosis.
Entrez Zusammenfassung
Heme oxygenase, an essential enzyme in heme catabolism, cleaves heme to form biliverdin, which is subsequently converted to bilirubin by biliverdin reductase, and carbon monoxide, a putative neurotransmitter. Heme oxygenase activity is induced by its substrate heme and by various nonheme substances. Heme oxygenase occurs as 2 isozymes, an inducible heme oxygenase-1 and a constitutive heme oxygenase-2. HMOX1 and HMOX2 belong to the heme oxygenase family.
Gewebespezifität
Expressed at higher levels in renal cancer tissue than in normal tissue (at protein level).
Rolle bei Krankheiten
Heme oxygenase 1 deficiency: A disease characterized by impaired stress hematopoiesis, resulting in marked erythrocyte fragmentation and intravascular hemolysis, coagulation abnormalities, endothelial damage, and iron deposition in renal and hepatic tissues. Clinical features include persistent hemolytic anemia, asplenia, nephritis, generalized erythematous rash, growth retardation and hepatomegaly.
Sequenzähnlichkeiten
Belongs to the heme oxygenase family.
Zellort
Microsome. Endoplasmic reticulum membrane.
