HIC1 ist ein Gen, das durch das Symbol HIC1 kodiert wird. Im Allgemeinen auch bezeichnet als: Hypermethylated in cancer 1 protein; Hic-1; Zinc finger and BTB domain-containing protein 29; ZBTB29. HIC1 hat eine Masse von 76.51kDa und eine Aminosäurelänge von 733.
Wir bieten 3 antikörper gegen HIC1, aufgewachsen in Kaninchen und Ziege, welche geeignet sind für WB and ELISA mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
Transcriptional repressor. Recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. May act as a tumor suppressor. May be involved in development of head, face, limbs and ventral body wall. Involved in down-regulation of SIRT1 and thereby is involved in regulation of p53/TP53-dependent apoptotic DNA-damage responses. The specific target gene promoter association seems to be depend on corepressors, such as CTBP1 or CTBP2 and MTA1. The regulation of SIRT1 transcription in response to nutrient deprivation seems to involve CTBP1. In cooperation with MTA1 (indicative for an association with the NuRD complex) represses transcription from CCND1/cyclin-D1 and CDKN1C/p57Kip2 specifically in quiescent cells. Involved in regulation of the Wnt signaling pathway probably by association with TCF7L2 and preventing TCF7L2 and CTNNB1 association with promoters of TCF-responsive genes. Seems to repress transcription from E2F1 and ATOH1 which involves ARID1A, indicative for the participation of a distinct SWI/SNF-type chromatin-remodeling complex. Probably represses transcription from ACKR3, FGFBP1 and EFNA1.
Entrez Zusammenfassung
This gene functions as a growth regulatory and tumor repressor gene. Hypermethylation or deletion of the region of this gene have been associated with tumors and the contiguous-gene syndrome, Miller-Dieker syndrome. Alternative splicing of this gene results in multiple transcript variants.
Gewebespezifität
Ubiquitously expressed with highest levels found in lung, colon, prostate, thymus, testis and ovary. Expression is absent or decreased in many tumor cells.
Sequenzähnlichkeiten
Belongs to the krueppel C2H2-type zinc-finger protein family. Hic subfamily.
Posttranslationale Modifikation
Acetylated on several residues, including Lys-333. Lys-333 is deacetylated by SIRT1.
