Histone H3 ist ein Gen, das durch das Symbol H3-IX kodiert wird. Im Allgemeinen auch bezeichnet als: Histone H3.3; H3-IX. Histone H3 hat eine Masse von 15.33kDa, eine Aminosäurelänge von 136, und ist an Glioma beteiligt.
Wir bieten 224 antikörper gegen Histone H3, aufgewachsen in Kaninchen und Maus, welche geeignet sind für WB, IHC, ELISA, ICC/IF, IP, Dot and ChIP mit Proben abgeleitet von Human, Maus, Ratte, Affe und Zebrafisch.
Gen- und Proteininformationen
UniProt Zusammenfassung
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Entrez Zusammenfassung
Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This histone pseudogene is found in the large histone gene cluster on chromosome 6.
Gewebespezifität
Low levels of expression in ovaries and moderate levels of expression in the testes. Highest levels of expression in embryos.
Rolle bei Krankheiten
Glioma: Gliomas are benign or malignant central nervous system neoplasms derived from glial cells. They comprise astrocytomas and glioblastoma multiforme that are derived from astrocytes, oligodendrogliomas derived from oligodendrocytes and ependymomas derived from ependymocytes.
Sequenzähnlichkeiten
Belongs to the histone H3 family.
Posttranslationale Modifikation
Acetylation is generally linked to gene activation.
Zellort
Nucleus. Chromosome.