Histone H4 ist ein Gen, das durch das Symbol H4C1 kodiert wird. Im Allgemeinen auch bezeichnet als: H4C1; H4/A; H4FA; HIST1H4A. Histone H4 hat eine Masse von 11.37kDa und eine Aminosäurelänge von 103.
Wir bieten 71 antikörper gegen Histone H4, aufgewachsen in Kaninchen, welche geeignet sind für WB, IHC, ELISA, ICC/IF, IP, Dot and ChIP mit Proben abgeleitet von Human, Maus, Ratte, Affe, Drosophila und Pflanzen.
Gen- und Proteininformationen
UniProt Zusammenfassung
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Entrez Zusammenfassung
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H4 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element.
Sequenzähnlichkeiten
Belongs to the histone H4 family.
Posttranslationale Modifikation
Acetylation at Lys-6 (H4K5ac), Lys-9 (H4K8ac), Lys-13 (H4K12ac) and Lys-17 (H4K16ac) occurs in coding regions of the genome but not in heterochromatin.
Zellort
Nucleus. Chromosome.
