ICAM3 ist ein Gen, das durch das Symbol ICAM3 kodiert wird. Im Allgemeinen auch bezeichnet als: Intercellular adhesion molecule 3; ICAM-3; CDw50; ICAM-R. ICAM3 hat eine Masse von 59.54kDa und eine Aminosäurelänge von 547.
Wir bieten 31 antikörper gegen ICAM3, aufgewachsen in Kaninchen und Maus, welche geeignet sind für WB, IHC, ELISA, ICC/IF, FC and IP mit Proben abgeleitet von Human.
Gen- und Proteininformationen
UniProt Zusammenfassung
ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2) (PubMed:1448173). ICAM3 is also a ligand for integrin alpha-D/beta-2. In association with integrin alpha-L/beta-2, contributes to apoptotic neutrophil phagocytosis by macrophages (PubMed:23775590).
Entrez Zusammenfassung
The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein is constitutively and abundantly expressed by all leucocytes and may be the most important ligand for LFA-1 in the initiation of the immune response. It functions not only as an adhesion molecule, but also as a potent signalling molecule. Alternative splicing results in multiple transcript variants encoding different isoforms.
Gewebespezifität
Leukocytes.
Sequenzähnlichkeiten
Belongs to the immunoglobulin superfamily. ICAM family.
Posttranslationale Modifikation
Upon stimulation by a physiologic stimuli becomes rapidly and transiently phosphorylated on serine residues.
