IL6 ist ein Gen, das durch das Symbol IL6 kodiert wird. Im Allgemeinen auch bezeichnet als: Interleukin-6; IL-6; B-cell stimulatory factor 2; BSF-2; CTL differentiation factor; CDF; Hybridoma growth factor; Interferon beta-2; IFN-beta-2; IFNB2. IL6 hat eine Masse von 23.72kDa, eine Aminosäurelänge von 212, und ist an Rheumatoid arthritis systemic juvenile beteiligt.
Wir bieten 73 antikörper gegen IL6, aufgewachsen in Kaninchen, Maus, Ziege, Ratte und Huhn, welche geeignet sind für WB, IHC, ELISA, ICC/IF, FC and sELISA mit Proben abgeleitet von Human, Maus, Ratte, Rind, Schwein, Kaninchen, Affe, Schaf, Huhn und Primaten.
Gen- und Proteininformationen
UniProt Zusammenfassung
Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation.
Entrez Zusammenfassung
This gene encodes a cytokine that functions in inflammation and the maturation of B cells. In addition, the encoded protein has been shown to be an endogenous pyrogen capable of inducing fever in people with autoimmune diseases or infections. The protein is primarily produced at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. The functioning of this gene is implicated in a wide variety of inflammation-associated disease states, including suspectibility to diabetes mellitus and systemic juvenile rheumatoid arthritis. Alternative splicing results in multiple transcript variants.
Rolle bei Krankheiten
Rheumatoid arthritis systemic juvenile: An inflammatory articular disorder with systemic-onset beginning before the age of 16. It represents a subgroup of juvenile arthritis associated with severe extraarticular features and occasionally fatal complications. During active phases of the disorder, patients display a typical daily spiking fever, an evanescent macular rash, lymphadenopathy, hepatosplenomegaly, serositis, myalgia and arthritis.
Sequenzähnlichkeiten
Belongs to the IL-6 superfamily.
Posttranslationale Modifikation
N- and O-glycosylated.
