iNOS ist ein Gen, das durch das Symbol NOS2 kodiert wird. Im Allgemeinen auch bezeichnet als: Nitric oxide synthase, inducible; Hepatocyte NOS; HEP-NOS; Inducible NO synthase; Inducible NOS; NOS type II; Peptidyl-cysteine S-nitrosylase NOS2; NOS2; NOS2A. iNOS hat eine Masse von 131.12kDa und eine Aminosäurelänge von 1153.
Wir bieten 18 antikörper gegen iNOS, aufgewachsen in Kaninchen, welche geeignet sind für WB, IHC, ELISA, ICC/IF and IP mit Proben abgeleitet von Human, Maus, Ratte und Rind.
Gen- und Proteininformationen
UniProt Zusammenfassung
Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body (PubMed:7531687, PubMed:7544004). In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such PTGS2/COX2 (By similarity). As component of the iNOS-S100A8/9 transnitrosylase complex involved in the selective inflammatory stimulus-dependent S-nitrosylation of GAPDH on 'Cys-247' implicated in regulation of the GAIT complex activity and probably multiple targets including ANXA5, EZR, MSN and VIM (PubMed:25417112). Involved in inflammation, enhances the synthesis of proinflammatory mediators such as IL6 and IL8 (PubMed:19688109).
Entrez Zusammenfassung
Nitric oxide is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission and antimicrobial and antitumoral activities. This gene encodes a nitric oxide synthase which is expressed in liver and is inducible by a combination of lipopolysaccharide and certain cytokines. Three related pseudogenes are located within the Smith-Magenis syndrome region on chromosome 17.
Gewebespezifität
Expressed in the liver, retina, bone cells and airway epithelial cells of the lung. Not expressed in the platelets.
Sequenzähnlichkeiten
Belongs to the NOS family.
Posttranslationale Modifikation
Polyubiquitinated; mediated by SPSB1, SPSB2 and SPSB4, leading to proteasomal degradation.
Zellort
Cytoplasm > Cytosol.
Localizes as discrete foci scattered throughout the cytosol and in the presence of SPSB1 and SPSB4, exhibits a more diffuse cytosolic localization.
