Isoleucyl tRNA synthetase ist ein Gen, das durch das Symbol IARS1 kodiert wird. Im Allgemeinen auch bezeichnet als: Isoleucine--tRNA ligase, cytoplasmic; Isoleucyl-tRNA synthetase; IRS; IARS1; IARS. Isoleucyl tRNA synthetase hat eine Masse von 144.5kDa, eine Aminosäurelänge von 1262, und ist an Growth retardation, impaired intellectual development, hypotonia, and hepatopathy beteiligt.
Wir bieten 1 antikörper gegen Isoleucyl tRNA synthetase, aufgewachsen in Kaninchen, welche geeignet sind für WB and IHC mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA.
Entrez Zusammenfassung
Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAS, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Isoleucine-tRNA synthetase belongs to the class-I aminoacyl-tRNA synthetase family and has been identified as a target of autoantibodies in the autoimmune disease polymyositis/dermatomyositis. Alternatively spliced transcript variants have been found.
Gewebespezifität
Expressed in liver and muscle (at protein level).
Rolle bei Krankheiten
Growth retardation, impaired intellectual development, hypotonia, and hepatopathy: An autosomal recessive disorder characterized by severe growth retardation with prenatal onset, intellectual disability, muscular hypotonia, and hepatic dysfunction.
Sequenzähnlichkeiten
Belongs to the class-I aminoacyl-tRNA synthetase family.
Zellort
Cytoplasm. Cytoplasm > Cytosol.
