LAMP2 ist ein Gen, das durch das Symbol LAMP2 kodiert wird. Im Allgemeinen auch bezeichnet als: Lysosome-associated membrane glycoprotein 2; LAMP-2; CD107 antigen-like family member B; LGP-96. LAMP2 hat eine Masse von 44.96kDa, eine Aminosäurelänge von 410, und ist an Danon disease beteiligt.
Wir bieten 26 antikörper gegen LAMP2, aufgewachsen in Kaninchen, Maus und Ratte, welche geeignet sind für WB, IHC, ELISA, ICC/IF, FC, IP and Dot mit Proben abgeleitet von Human, Maus, Ratte, Kaninchen und Hund.
Gen- und Proteininformationen
UniProt Zusammenfassung
Plays an important role in chaperone-mediated autophagy, a process that mediates lysosomal degradation of proteins in response to various stresses and as part of the normal turnover of proteins with a long biological half-live (PubMed:8662539, PubMed:11082038, PubMed:18644871, PubMed:24880125, PubMed:27628032). Functions by binding target proteins, such as GAPDH and MLLT11, and targeting them for lysosomal degradation (PubMed:8662539, PubMed:11082038, PubMed:18644871, PubMed:24880125). Plays a role in lysosomal protein degradation in response to starvation (By similarity). Required for the fusion of autophagosomes with lysosomes during autophagy (PubMed:27628032). Cells that lack LAMP2 express normal levels of VAMP8, but fail to accumulate STX17 on autophagosomes, which is the most likely explanation for the lack of fusion between autophagosomes and lysosomes (PubMed:27628032). Required for normal degradation of the contents of autophagosomes (PubMed:27628032). Required for efficient MHCII-mediated presentation of exogenous antigens via its function in lysosomal protein degradation; antigenic peptides generated by proteases in the endosomal/lysosomal compartment are captured by nascent MHCII subunits (PubMed:20518820). Is not required for efficient MHCII-mediated presentation of endogenous antigens (PubMed:20518820).
Entrez Zusammenfassung
The protein encoded by this gene is a member of a family of membrane glycoproteins. This glycoprotein provides selectins with carbohydrate ligands. It may play a role in tumor cell metastasis. It may also function in the protection, maintenance, and adhesion of the lysosome. Alternative splicing of this gene results in multiple transcript variants encoding distinct proteins.
Gewebespezifität
Isoform LAMP-2A is highly expressed in placenta, lung and liver, less in kidney and pancreas, low in brain and skeletal muscle (PubMed:7488019, PubMed:26856698). Isoform LAMP-2B is detected in spleen, thymus, prostate, testis, small intestine, colon, skeletal muscle, brain, placenta, lung, kidney, ovary and pancreas and liver (PubMed:7488019, PubMed:26856698). Isoform LAMP-2C is detected in small intestine, colon, heart, brain, skeletal muscle, and at lower levels in kidney and placenta (PubMed:26856698).
Rolle bei Krankheiten
Danon disease: DAND is a lysosomal glycogen storage disease characterized by the clinical triad of cardiomyopathy, vacuolar myopathy and mental retardation. It is often associated with an accumulation of glycogen in muscle and lysosomes.
Sequenzähnlichkeiten
Belongs to the LAMP family.
Posttranslationale Modifikation
O- and N-glycosylated; some of the 16 N-linked glycans are polylactosaminoglycans.
Zellort
Cell membrane. Endosome membrane. Lysosome membrane. Cytoplasmic vesicle > Autophagosome membrane.
This protein shuttles between lysosomes, endosomes, and the plasma membrane.
