Luteinizing Hormone ist ein Gen, das durch das Symbol LHB kodiert wird. Im Allgemeinen auch bezeichnet als: Lutropin subunit beta; Lutropin beta chain subunit beta; LH-B; LHB. Luteinizing Hormone hat eine Masse von 15.35kDa, eine Aminosäurelänge von 141, und ist an Hypogonadotropic hypogonadism 23 without anosmia beteiligt.
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Gen- und Proteininformationen
UniProt Zusammenfassung
Promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids.
Entrez Zusammenfassung
This gene is a member of the glycoprotein hormone beta chain family and encodes the beta subunit of luteinizing hormone (LH). Glycoprotein hormones are heterodimers consisting of a common alpha subunit and an unique beta subunit which confers biological specificity. LH is expressed in the pituitary gland and promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids. The genes for the beta chains of chorionic gonadotropin and for luteinizing hormone are contiguous on chromosome 19q13.3. Mutations in this gene are associated with hypogonadism which is characterized by infertility and pseudohermaphroditism.
Gewebespezifität
Pituitary gland.
Rolle bei Krankheiten
Hypogonadotropic hypogonadism 23 without anosmia: A form of hypogonadotropic hypogonadism, a group of disorders characterized by absent or incomplete sexual maturation by the age of 18 years, in conjunction with low levels of circulating gonadotropins and testosterone and no other abnormalities of the hypothalamic-pituitary axis. HH23 male patients have normal sexual differentiation, reduced or absent Leydig cells, reduced or absent spermatogenesis, and absence of spontaneous puberty. Female patients exhibit normal pubertal development and menarche, followed by oligomenorrhea and anovulatory secondary amenorrhea.
Sequenzähnlichkeiten
Belongs to the glycoprotein hormones subunit beta family.
