MADH7 ist ein Gen, das durch das Symbol SMAD7 kodiert wird. Im Allgemeinen auch bezeichnet als: Mothers against decapentaplegic homolog 7; MAD homolog 7; Mothers against decapentaplegic homolog 8; MAD homolog 8; SMAD family member 7; SMAD 7; SMAD7; MADH8. MADH7 hat eine Masse von 46.43kDa, eine Aminosäurelänge von 426, und ist an Colorectal cancer 3 beteiligt.
Wir bieten 2 antikörper gegen MADH7, aufgewachsen in Kaninchen, welche geeignet sind für WB and IHC mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit TGF-beta (Transforming growth factor) and activin signaling by associating with their receptors thus preventing SMAD2 access. Functions as an adapter to recruit SMURF2 to the TGF-beta receptor complex. Also acts by recruiting the PPP1R15A-PP1 complex to TGFBR1, which promotes its dephosphorylation. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.
Entrez Zusammenfassung
The protein encoded by this gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding, this complex translocates to the cytoplasm, where it interacts with TGF-beta receptor type-1 (TGFBR1), leading to the degradation of both the encoded protein and TGFBR1. Expression of this gene is induced by TGFBR1. Variations in this gene are a cause of susceptibility to colorectal cancer type 3 (CRCS3). Several transcript variants encoding different isoforms have been found for this gene.
Gewebespezifität
Ubiquitous with higher expression in the lung and vascular endothelium.
Rolle bei Krankheiten
Colorectal cancer 3: A complex disease characterized by malignant lesions arising from the inner wall of the large intestine (the colon) and the rectum. Genetic alterations are often associated with progression from premalignant lesion (adenoma) to invasive adenocarcinoma. Risk factors for cancer of the colon and rectum include colon polyps, long-standing ulcerative colitis, and genetic family history.
Sequenzähnlichkeiten
Belongs to the dwarfin/SMAD family.
Posttranslationale Modifikation
Phosphorylation on Ser-249 does not affect its stability, nuclear localization or inhibitory function in TGFB signaling; however it affects its ability to regulate transcription (By similarity). Phosphorylated by PDPK1.
Zellort
Nucleus. Cytoplasm.
Interaction with NEDD4L or RNF111 induces translocation from the nucleus to the cytoplasm (PubMed:16601693). TGF-beta stimulates its translocation from the nucleus to the cytoplasm. PDPK1 inhibits its translocation from the nucleus to the cytoplasm in response to TGF-beta (PubMed:17327236).
