MCL1 ist ein Gen, das durch das Symbol MCL1 kodiert wird. Im Allgemeinen auch bezeichnet als: Induced myeloid leukemia cell differentiation protein Mcl-1; Bcl-2-like protein 3; Bcl2-L-3; Bcl-2-related protein EAT/mcl1/EAT; BCL2L3. MCL1 hat eine Masse von 37.34kDa und eine Aminosäurelänge von 350.
Wir bieten 23 antikörper gegen MCL1, aufgewachsen in Kaninchen und Ziege, welche geeignet sind für WB, IHC, ELISA, ICC/IF and FC mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis.
Entrez Zusammenfassung
This gene encodes an anti-apoptotic protein, which is a member of the Bcl-2 family. Alternative splicing results in multiple transcript variants. The longest gene product (isoform 1) enhances cell survival by inhibiting apoptosis while the alternatively spliced shorter gene products (isoform 2 and isoform 3) promote apoptosis and are death-inducing.
Sequenzähnlichkeiten
Belongs to the Bcl-2 family.
Posttranslationale Modifikation
Cleaved by CASP3 during apoptosis. In intact cells cleavage occurs preferentially after Asp-127, yielding a pro-apoptotic 28 kDa C-terminal fragment.
Zellort
Membrane. Cytoplasm. Mitochondrion. Nucleus > Nucleoplasm.
Cytoplasmic, associated with mitochondria.