MCM7 ist ein Gen, das durch das Symbol MCM7 kodiert wird. Im Allgemeinen auch bezeichnet als: DNA replication licensing factor CDC47 homolog; P1.1-MCM3; CDC47; MCM2. MCM7 hat eine Masse von 81.31kDa und eine Aminosäurelänge von 719.
Wir bieten 23 antikörper gegen MCM7, aufgewachsen in Kaninchen und Maus, welche geeignet sind für WB, IHC, ELISA, ICC/IF, FC, IP and ChIP mit Proben abgeleitet von Human, Maus, Ratte, Hamster und S. pombe.
Gen- und Proteininformationen
UniProt Zusammenfassung
Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for S-phase checkpoint activation upon UV-induced damage.
Entrez Zusammenfassung
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 6 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. Cyclin D1-dependent kinase, CDK4, is found to associate with this protein, and may regulate the binding of this protein with the tumorsuppressor protein RB1/RB. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
Sequenzähnlichkeiten
Belongs to the MCM family.
Posttranslationale Modifikation
O-glycosylated (O-GlcNAcylated), in a cell cycle-dependent manner.
