MMP3 ist ein Gen, das durch das Symbol MMP3 kodiert wird. Im Allgemeinen auch bezeichnet als: Stromelysin-1; SL-1; Matrix metalloproteinase-3; MMP-3; Transin-1; STMY1. MMP3 hat eine Masse von 53.98kDa, eine Aminosäurelänge von 477, und ist an Coronary heart disease 6 beteiligt.
Wir bieten 24 antikörper gegen MMP3, aufgewachsen in Kaninchen, Maus und Ziege, welche geeignet sind für WB, IHC, ELISA, ICC/IF and FC mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
Can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates procollagenase.
Entrez Zusammenfassung
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes an enzyme which degrades fibronectin, laminin, collagens III, IV, IX, and X, and cartilage proteoglycans. The enzyme is thought to be involved in wound repair, progression of atherosclerosis, and tumor initiation. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3.
Rolle bei Krankheiten
Coronary heart disease 6: A multifactorial disease characterized by an imbalance between myocardial functional requirements and the capacity of the coronary vessels to supply sufficient blood flow. Decreased capacity of the coronary vessels is often associated with thickening and loss of elasticity of the coronary arteries.
Sequenzähnlichkeiten
Belongs to the peptidase M10A family.
Zellort
Secreted > Extracellular space > Extracellular matrix.
