MMP7 ist ein Gen, das durch das Symbol MMP7 kodiert wird. Im Allgemeinen auch bezeichnet als: Matrilysin; Matrin; Matrix metalloproteinase-7; MMP-7; Pump-1 protease; Uterine metalloproteinase; MPSL1; PUMP1. MMP7 hat eine Masse von 29.68kDa und eine Aminosäurelänge von 267.
Wir bieten 12 antikörper gegen MMP7, aufgewachsen in Kaninchen, Maus und Ziege, welche geeignet sind für WB, IHC, ELISA, ICC/IF and ChIP mit Proben abgeleitet von Human, Maus, Ratte und Affe.
Gen- und Proteininformationen
UniProt Zusammenfassung
Degrades casein, gelatins of types I, III, IV, and V, and fibronectin. Activates procollagenase.
Entrez Zusammenfassung
This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. This secreted protease breaks down proteoglycans, fibronectin, elastin and casein and differs from most MMP family members in that it lacks a conserved C-terminal hemopexin domain. The enzyme is involved in wound healing, and studies in mice suggest that it regulates the activity of defensins in intestinal mucosa. The gene is part of a cluster of MMP genes on chromosome 11. This gene exhibits elevated expression levels in multiple human cancers.
Sequenzähnlichkeiten
Belongs to the peptidase M10A family.
Zellort
Secreted > Extracellular space > Extracellular matrix.
