MTMR3 ist ein Gen, das durch das Symbol MTMR3 kodiert wird. Im Allgemeinen auch bezeichnet als: Myotubularin-related protein 3; FYVE domain-containing dual specificity protein phosphatase 1; FYVE-DSP1; Phosphatidylinositol-3,5-bisphosphate 3-phosphatase; Phosphatidylinositol-3-phosphate phosphatase; Zinc finger FYVE domain-containing protein 10; KIAA0371; ZFYVE10. MTMR3 hat eine Masse von 133.62kDa und eine Aminosäurelänge von 1198.
Wir bieten 1 antikörper gegen MTMR3, aufgewachsen in Kaninchen, welche geeignet sind für WB and ICC/IF mit Proben abgeleitet von Human und Maus.
Gen- und Proteininformationen
UniProt Zusammenfassung
Phosphatase that acts on lipids with a phosphoinositol headgroup. Has phosphatase activity towards phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate. May also dephosphorylate proteins phosphorylated on Ser, Thr, and Tyr residues (PubMed:10733931).
Entrez Zusammenfassung
This gene encodes a member of the myotubularin dual specificity protein phosphatase gene family. The encoded protein is structurally similar to myotubularin but in addition contains a FYVE domain and an N-terminal PH-GRAM domain. The protein can self-associate and also form heteromers with another myotubularin related protein. The protein binds to phosphoinositide lipids through the PH-GRAM domain, and can hydrolyze phosphatidylinositol(3)-phosphate and phosphatidylinositol(3,5)-biphosphate in vitro. The encoded protein has been observed to have a perinuclear, possibly membrane-bound, distribution in cells, but it has also been found free in the cytoplasm. Multiple transcript variants encoding different isoforms have been found for this gene.
Sequenzähnlichkeiten
Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
Zellort
Cytoplasm. Membrane.
