NAPSIN A ist ein Gen, das durch das Symbol NAPSA kodiert wird. Im Allgemeinen auch bezeichnet als: Napsin-A; Aspartyl protease 4; ASP4; Napsin-1; TA01/TA02; NAPSA; NAP1; NAPA. NAPSIN A hat eine Masse von 45.39kDa und eine Aminosäurelänge von 420.
Wir bieten 46 antikörper gegen NAPSIN A, aufgewachsen in Kaninchen und Maus, welche geeignet sind für WB, IHC, ELISA, ICC/IF, FC, IP and ChIP mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
May be involved in processing of pneumocyte surfactant precursors.
Entrez Zusammenfassung
This gene encodes a member of the peptidase A1 family of aspartic proteases. The encoded preproprotein is proteolytically processed to generate an activation peptide and the mature protease. The activation peptides of aspartic proteinases function as inhibitors of the protease active site. These peptide segments, or pro-parts, are deemed important for correct folding, targeting, and control of the activation of aspartic proteinase zymogens. The encoded protease may play a role in the proteolytic processing of pulmonary surfactant protein B in the lung and may function in protein catabolism in the renal proximal tubules. This gene has been described as a marker for lung adenocarcinoma and renal cell carcinoma.
Gewebespezifität
Expressed predominantly in adult lung (type II pneumocytes) and kidney and in fetal lung. Low levels in adult spleen and very low levels in peripheral blood leukocytes.
Sequenzähnlichkeiten
Belongs to the peptidase A1 family.
