Nectin 2 ist ein Gen, das durch das Symbol NECTIN2 kodiert wird. Im Allgemeinen auch bezeichnet als: Nectin-2; Herpes virus entry mediator B; Herpesvirus entry mediator B; Nectin cell adhesion molecule 2; Poliovirus receptor-related protein 2; NECTIN2; HVEB; PRR2; PVRL2. Nectin 2 hat eine Masse von 57.74kDa und eine Aminosäurelänge von 538.
Wir bieten 10 antikörper gegen Nectin 2, aufgewachsen in Kaninchen und Maus, welche geeignet sind für WB, IHC, ELISA, ICC/IF, FC and IP mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
Modulator of T-cell signaling. Can be either a costimulator of T-cell function, or a coinhibitor, depending on the receptor it binds to. Upon binding to CD226, stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG. Upon interaction with PVRIG, inhibits T-cell proliferation. These interactions are competitive (PubMed:26755705). Probable cell adhesion protein (PubMed:9657005).
Entrez Zusammenfassung
This gene encodes a single-pass type I membrane glycoprotein with two Ig-like C2-type domains and an Ig-like V-type domain. This protein is one of the plasma membrane components of adherens junctions. It also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and it is involved in cell to cell spreading of these viruses. Variations in this gene have been associated with differences in the severity of multiple sclerosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Gewebespezifität
Ubiquitous.
Sequenzähnlichkeiten
Belongs to the nectin family.
