NeuN ist ein Gen, das durch das Symbol RBFOX3 kodiert wird. Im Allgemeinen auch bezeichnet als: RNA binding protein fox-1 homolog 3; Fox-1 homolog C; Neuronal nuclei antigen antigen; RBFOX3. NeuN hat eine Masse von 33.87kDa und eine Aminosäurelänge von 312.
Wir bieten 31 antikörper gegen NeuN, aufgewachsen in Kaninchen, Maus, Ziege und Huhn, welche geeignet sind für WB, IHC, ICC/IF and FC mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
Pre-mRNA alternative splicing regulator. Regulates alternative splicing of RBFOX2 to enhance the production of mRNA species that are targeted for nonsense-mediated decay (NMD).
Entrez Zusammenfassung
This gene encodes a member of the RNA-binding FOX protein family which is involved in the regulation of alternative splicing of pre-mRNA. The protein has an N-terminal proline-rich region, an RNA recognition motif (RRM) domain, and a C-terminal alanine-rich region. This gene produces the neuronal nuclei (NeuN) antigen that has been widely used as a marker for post-mitotic neurons. This gene has its highest expression in the central nervous system and plays a prominent role in neural tissue development and regulation of adult brain function. Mutations in this gene have been associated with numerous neurological disorders. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms.
Zellort
Nucleus. Cytoplasm.
Largely restricted to neuronal nuclei. However, significant cytoplasmic localization in neurons from brains from HIV-infected individuals with cognitive impairment.
