Neurochondrin ist ein Gen, das durch das Symbol NCDN kodiert wird. Im Allgemeinen auch bezeichnet als: NCDN; KIAA0607. Neurochondrin hat eine Masse von 78.86kDa und eine Aminosäurelänge von 729.
Wir bieten 5 antikörper gegen Neurochondrin, aufgewachsen in Kaninchen und Ziege, welche geeignet sind für WB, IHC, ELISA, ICC/IF and IP mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
Probably involved in signal transduction, in the nervous system, via increasing cell surface localization of GRM5 and positively regulating its signaling (By similarity). Required for the spatial learning process. Acts as a negative regulator of Ca(2+)-calmodulin-dependent protein kinase 2 (CaMK2) phosphorylation. May play a role in modulating melanin-concentrating hormone-mediated functions via its interaction with MCHR1 that interferes with G protein-coupled signal transduction. May be involved in bone metabolism. May also be involved in neurite outgrowth.
Entrez Zusammenfassung
This gene encodes a leucine-rich cytoplasmic protein, which is highly similar to a mouse protein that negatively regulates Ca/calmodulin-dependent protein kinase II phosphorylation and may be essential for spatial learning processes. Several alternatively spliced transcript variants of this gene have been described.
Gewebespezifität
Abundantly expressed in whole adult brain and in all individual brain regions examined, including spinal cord. Weakly expressed in ovary, testis, fetal brain and small intestine.
Sequenzähnlichkeiten
Belongs to the neurochondrin family.
Posttranslationale Modifikation
Palmitoylated. Palmitoylation by ZDHHC1, ZDHHC3 and ZDHHC11 regulates the association of NCDN with endosome membranes. May also be palmitoylated by ZDHHC7.
Zellort
Cytoplasm > Cytosol. Endosome membrane. Cell projection > Dendrite. Cell junction > Synapse > Postsynapse.
Localizes to somatic regions of neurons. Localization to endosome membrane requires palmitoylation.
