OB Cadherin ist ein Gen, das durch das Symbol CDH11 kodiert wird. Im Allgemeinen auch bezeichnet als: Cadherin-11; OSF-4; Osteoblast cadherin; OB-cadherin; CDH11. OB Cadherin hat eine Masse von 87.97kDa, eine Aminosäurelänge von 796, und ist an Elsahy-Waters syndrome beteiligt.
Wir bieten 11 antikörper gegen OB Cadherin, aufgewachsen in Kaninchen, Maus und Ziege, welche geeignet sind für WB, IHC, ELISA and ICC/IF mit Proben abgeleitet von Human, Maus, Ratte und Zebrafisch.
Gen- und Proteininformationen
UniProt Zusammenfassung
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
Entrez Zusammenfassung
This gene encodes a type II classical cadherin from the cadherin superfamily, integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. Expression of this particular cadherin in osteoblastic cell lines, and its upregulation during differentiation, suggests a specific function in bone development and maintenance.
Gewebespezifität
Expressed mainly in brain but also found in other tissues. Expressed in neuroblasts.
Rolle bei Krankheiten
Elsahy-Waters syndrome: An autosomal recessive syndrome characterized by moderate mental retardation, hypospadias and characteristic craniofacial morphology, which includes brachycephaly, facial asymmetry, exotropia, hypertelorism, telechantus, broad nose, concave nasal ridge, underdeveloped mid-face, prognathism, and radicular dentin dysplasia.
