Ornithine Decarboxylase ist ein Gen, das durch das Symbol ODC1 kodiert wird. Im Allgemeinen auch bezeichnet als: ODC; ODC1. Ornithine Decarboxylase hat eine Masse von 51.15kDa und eine Aminosäurelänge von 461.
Wir bieten 17 antikörper gegen Ornithine Decarboxylase, aufgewachsen in Kaninchen und Maus, welche geeignet sind für WB, IHC, ELISA, ICC/IF and FC mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis.
Entrez Zusammenfassung
This gene encodes the rate-limiting enzyme of the polyamine biosynthesis pathway which catalyzes ornithine to putrescine. The activity level for the enzyme varies in response to growth-promoting stimuli and exhibits a high turnover rate in comparison to other mammalian proteins. Originally localized to both chromosomes 2 and 7, the gene encoding this enzyme has been determined to be located on 2p25, with a pseudogene located on 7q31-qter. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified.
Sequenzähnlichkeiten
Belongs to the Orn/Lys/Arg decarboxylase class-II family.
Posttranslationale Modifikation
S-Nitrosylation inhibits the enzyme. S-Nitrosylated in vitro on 4 cysteine residues.
