PKA regulatory subunit I beta ist ein Gen, das durch das Symbol PRKAR1B kodiert wird. Im Allgemeinen auch bezeichnet als: cAMP-dependent protein kinase type I-beta regulatory subunit; PRKAR1B. PKA regulatory subunit I beta hat eine Masse von 43.07kDa und eine Aminosäurelänge von 381.
Wir bieten 3 antikörper gegen PKA regulatory subunit I beta, aufgewachsen in Kaninchen, welche geeignet sind für WB, IHC and ELISA mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells.
Entrez Zusammenfassung
The protein encoded by this gene is a regulatory subunit of cyclic AMP-dependent protein kinase A (PKA), which is involved in the signaling pathway of the second messenger cAMP. Two regulatory and two catalytic subunits form the PKA holoenzyme, disbands after cAMP binding. The holoenzyme is involved in many cellular events, including ion transport, metabolism, and transcription. Several transcript variants encoding the same protein have been found for this gene.
Gewebespezifität
Four types of regulatory chains are found: I-alpha, I-beta, II-alpha, and II-beta. Their expression varies among tissues and is in some cases constitutive and in others inducible.
Sequenzähnlichkeiten
Belongs to the cAMP-dependent kinase regulatory chain family.
Posttranslationale Modifikation
The pseudophosphorylation site binds to the substrate-binding region of the catalytic chain, resulting in the inhibition of its activity.
