PPP2R1B ist ein Gen, das durch das Symbol PPP2R1B kodiert wird. Im Allgemeinen auch bezeichnet als: Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform; PP2A subunit A isoform PR65-beta; PP2A subunit A isoform R1-beta. PPP2R1B hat eine Masse von 66.21kDa und eine Aminosäurelänge von 601.
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Gen- und Proteininformationen
UniProt Zusammenfassung
The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit.
Entrez Zusammenfassung
This gene encodes a constant regulatory subunit of protein phosphatase 2. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The constant regulatory subunit A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. This gene encodes a beta isoform of the constant regulatory subunit A. Mutations in this gene have been associated with some lung and colon cancers. Alternatively spliced transcript variants have been described.
Sequenzähnlichkeiten
Belongs to the phosphatase 2A regulatory subunit A family.
