PPP2R5A ist ein Gen, das durch das Symbol PPP2R5A kodiert wird. Im Allgemeinen auch bezeichnet als: Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform; PP2A B subunit isoform B'-alpha; PP2A B subunit isoform B56-alpha; PP2A B subunit isoform PR61-alpha; PR61alpha; PP2A B subunit isoform R5-alpha. PPP2R5A hat eine Masse von 56.19kDa und eine Aminosäurelänge von 486.
Wir bieten 6 antikörper gegen PPP2R5A, aufgewachsen in Kaninchen und Ziege, welche geeignet sind für WB, IHC, ELISA and ICC/IF mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.
Entrez Zusammenfassung
The product of this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes an alpha isoform of the regulatory subunit B56 subfamily. Alternative transcript variants encoding distinct isoforms have been found for this gene.
Gewebespezifität
Widely expressed with the highest expression in heart and skeletal muscle.
Sequenzähnlichkeiten
Belongs to the phosphatase 2A regulatory subunit B56 family.
Posttranslationale Modifikation
Phosphorylated on serine residues.
Zellort
Cytoplasm. Nucleus. Chromosome > Centromere.
From mitotic prophase to metaphase, localizes at the inner centromere between a pair of sister kinetochores. Decreased expression at the onset of anaphase.
