PRDM14 ist ein Gen, das durch das Symbol PRDM14 kodiert wird. Im Allgemeinen auch bezeichnet als: PR domain zinc finger protein 14; PR domain-containing protein 14. PRDM14 hat eine Masse von 64.06kDa und eine Aminosäurelänge von 571.
Wir bieten 10 antikörper gegen PRDM14, aufgewachsen in Kaninchen und Ziege, welche geeignet sind für WB, IHC, ELISA, ICC/IF, FC, IP and ChIP mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
Transcription factor that has both positive and negative roles on transcription. Required for the maintenance of embryonic stem cell identity and the reacquisition of pluripotency in somatic cells. May play an essential role in germ cell development at 2 levels: the reacquisition of potential pluripotency, including SOX2 up-regulation, and successful epigenetic reprogramming, characterized by EHMT1 repression. Its association with CBFA2T2 is required for the functions in pluripotency and germ cell formation (By similarity). Directly up-regulates the expression of pluripotency gene POU5F1 through its proximal enhancer. Binds to the DNA consensus sequence 5'-GGTC[TC]CTAA-3'.
Entrez Zusammenfassung
This gene encodes a member of the PRDI-BF1 and RIZ homology domain containing (PRDM) family of transcriptional regulators. The encoded protein may possess histone methyltransferase activity and plays a critical role in cell pluripotency by suppressing the expression of differentiation marker genes. Expression of this gene may play a role in breast cancer.
Gewebespezifität
Expressed in embryonic stem cells. Tends to be overexpressed in breast cancer (at protein level).
Sequenzähnlichkeiten
Belongs to the class V-like SAM-binding methyltransferase superfamily.
