RIP140 ist ein Gen, das durch das Symbol NRIP1 kodiert wird. Es ist auch bekannt als: Nuclear receptor-interacting protein 1; Nuclear factor Receptor-interacting protein 140; NRIP1. RIP140 hat eine Masse von 126.94kDa, eine Aminosäurelänge von 1158, und ist an Congenital anomalies of kidney and urinary tract 3 beteiligt.
Wir bieten 14 antikörper gegen RIP140, aufgewachsen in Kaninchen und Ziege, welche geeignet sind für WB, IHC, ELISA, ICC/IF, IP and ChIP mit Proben abgeleitet von Human, Maus, Ratte, Affe und Huhn.
Gen- und Proteininformationen
UniProt Zusammenfassung
Modulates transcriptional activation by steroid receptors such as NR3C1, NR3C2 and ESR1. Also modulates transcriptional repression by nuclear hormone receptors. Positive regulator of the circadian clock gene expression: stimulates transcription of ARNTL/BMAL1, CLOCK and CRY1 by acting as a coactivator for RORA and RORC. Involved in the regulation of ovarian function (By similarity). Plays a role in renal development (PubMed:28381549).
Entrez Zusammenfassung
Nuclear receptor interacting protein 1 (NRIP1) is a nuclear protein that specifically interacts with the hormone-dependent activation domain AF2 of nuclear receptors. Also known as RIP140, this protein modulates transcriptional activity of the estrogen receptor.
Rolle bei Krankheiten
Congenital anomalies of kidney and urinary tract 3: A disorder encompassing a broad spectrum of renal and urinary tract malformations that include renal agenesis, kidney hypodysplasia, multicystic kidney dysplasia, duplex collecting system, posterior urethral valves and ureter abnormalities. Congenital anomalies of kidney and urinary tract are the commonest cause of chronic kidney disease in children. CAKUT3 inheritance is autosomal dominant.
Posttranslationale Modifikation
Acetylation regulates its nuclear translocation and corepressive activity (By similarity). Acetylation abolishes interaction with CTBP1. Phosphorylation enhances interaction with YWHAH.
Zellort
Nucleus.
Localized to discrete foci and redistributes to larger nuclear domains upon binding to ligand-bound NR3C1.
