Scavenging Receptor SR-BI ist ein Gen, das durch das Symbol SCARB1 kodiert wird. Es ist auch bekannt als: Scavenger receptor class B member 1; SRB1; CD36 and LIMPII analogous 1; CLA-1; CD36 antigen-like 1; Collagen type I receptor, thrombospondin receptor-like 1; SR-BI; SCARB1; CD36L1; CLA1. Scavenging Receptor SR-BI hat eine Masse von 60.88kDa und eine Aminosäurelänge von 552.
Wir bieten 8 antikörper gegen Scavenging Receptor SR-BI, aufgewachsen in Kaninchen und Ziege, welche geeignet sind für WB, IHC, ELISA, ICC/IF and FC mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
Receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells (PubMed:12016218, PubMed:12519372, PubMed:21226579). Receptor for HDL, mediating selective uptake of cholesteryl ether and HDL-dependent cholesterol efflux (PubMed:26965621). Also facilitates the flux of free and esterified cholesterol between the cell surface and apoB-containing lipoproteins and modified lipoproteins, although less efficiently than HDL. May be involved in the phagocytosis of apoptotic cells, via its phosphatidylserine binding activity (PubMed:12016218).
Entrez Zusammenfassung
The protein encoded by this gene is a plasma membrane receptor for high density lipoprotein cholesterol (HDL). The encoded protein mediates cholesterol transfer to and from HDL. In addition, this protein is a receptor for hepatitis C virus glycoprotein E2. Two transcript variants encoding different isoforms have been found for this gene.
Gewebespezifität
Widely expressed.
Sequenzähnlichkeiten
Belongs to the CD36 family.
Posttranslationale Modifikation
N-glycosylated.
Zellort
Cell membrane. Membrane > Caveola.
Predominantly localized to cholesterol and sphingomyelin-enriched domains within the plasma membrane, called caveolae.
