Secretogranin 3 ist ein Gen, das durch das Symbol SCG3 kodiert wird. Es ist auch bekannt als: Secretogranin-3; Secretogranin III; SgIII; SCG3. Secretogranin 3 hat eine Masse von 53.01kDa und eine Aminosäurelänge von 468.
Wir bieten 4 antikörper gegen Secretogranin 3, aufgewachsen in Kaninchen, welche geeignet sind für WB, IHC and ELISA mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
Member of the granin protein family that regulates the biogenesis of secretory granules (PubMed:19357184). Acts as a sorting receptor for intragranular proteins including chromogranin A/CHGA (By similarity). May also play a role in angiogenesis. Promotes endothelial proliferation, migration and tube formation through MEK/ERK signaling pathway (PubMed:29154827).
Entrez Zusammenfassung
The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. Granins may serve as precursors for biologically active peptides. Some granins have been shown to function as helper proteins in sorting and proteolytic processing of prohormones; however, the function of this protein is unknown. Two transcript variants encoding different isoforms have been found for this gene.
Gewebespezifität
Expressed in brain, heart, kidney, liver and skeletal muscle.
Posttranslationale Modifikation
O-glycosylated.
Zellort
Cytoplasmic vesicle > Secretory vesicle. Cytoplasmic vesicle > Secretory vesicle membrane. Secreted.
Associated with the secretory granule membrane through direct binding to cholesterol-enriched lipid rafts.
