SMCR7L ist ein Gen, das durch das Symbol MIEF1 kodiert wird. Es ist auch bekannt als: Mitochondrial dynamics protein MID51; Mitochondrial dynamics protein of 51 kDa; Mitochondrial elongation factor 1; Smith-Magenis syndrome chromosomal region candidate gene 7 protein-like; SMCR7-like protein; MIEF1; MID51. SMCR7L hat eine Masse von 51.29kDa und eine Aminosäurelänge von 463.
Wir bieten 1 antikörper gegen SMCR7L, aufgewachsen in Kaninchen, welche geeignet sind für WB mit Proben abgeleitet von Human.
Gen- und Proteininformationen
UniProt Zusammenfassung
Mitochondrial outer membrane protein which regulates mitochondrial fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface independently of the mitochondrial fission FIS1 and MFF proteins. Regulates DNM1L GTPase activity and DNM1L oligomerization. Binds ADP and can also bind GDP, although with lower affinity. Does not bind CDP, UDP, ATP, AMP or GTP. Inhibits DNM1L GTPase activity in the absence of bound ADP. Requires ADP to stimulate DNM1L GTPase activity and the assembly of DNM1L into long, oligomeric tubules with a spiral pattern, as opposed to the ring-like DNM1L oligomers observed in the absence of bound ADP. Does not require ADP for its function in recruiting DNM1L.
Gewebespezifität
Expression is relatively high in heart, skeletal muscle, pancreas and kidney.
Sequenzähnlichkeiten
Belongs to the SMCR7 family.
Zellort
Mitochondrion outer membrane.
