Somatostatin ist ein Gen, das durch das Symbol SST kodiert wird. Es ist auch bekannt als: Growth hormone release-inhibiting factor; SST. Somatostatin hat eine Masse von 12.74kDa und eine Aminosäurelänge von 116.
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Gen- und Proteininformationen
UniProt Zusammenfassung
Inhibits the secretion of pituitary hormones, including that of growth hormone/somatotropin (GH1), PRL, ACTH, luteinizing hormone (LH) and TSH. Also impairs ghrelin- and GnRH-stimulated secretion of GH1 and LH; the inhibition of ghrelin-stimulated secretion of GH1 can be further increased by neuronostatin.
Entrez Zusammenfassung
The hormone somatostatin has active 14 aa and 28 aa forms that are produced by alternate cleavage of the single preproprotein encoded by this gene. Somatostatin is expressed throughout the body and inhibits the release of numerous secondary hormones by binding to high-affinity G-protein-coupled somatostatin receptors. This hormone is an important regulator of the endocrine system through its interactions with pituitary growth hormone, thyroid stimulating hormone, and most hormones of the gastrointestinal tract. Somatostatin also affects rates of neurotransmission in the central nervous system and proliferation of both normal and tumorigenic cells.
Sequenzähnlichkeiten
Belongs to the somatostatin family.
Posttranslationale Modifikation
C-terminal amidation of the neuronostatin peptide is required for its biological activity, including for the regulation of mean arterial pressure.
