STK39 ist ein Gen, das durch das Symbol STK39 kodiert wird. Es ist auch bekannt als: STE20/SPS1-related proline-alanine-rich protein kinase; Ste-20-related kinase; DCHT; Serine/threonine-protein kinase 39; SPAK. STK39 hat eine Masse von 59.47kDa und eine Aminosäurelänge von 545.
Wir bieten 17 antikörper gegen STK39, aufgewachsen in Kaninchen und Ziege, welche geeignet sind für WB, IHC and ELISA mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
May act as a mediator of stress-activated signals. Mediates the inhibition of SLC4A4, SLC26A6 as well as CFTR activities by the WNK scaffolds, probably through phosphorylation. Phosphorylates RELT.
Entrez Zusammenfassung
This gene encodes a serine/threonine kinase that is thought to function in the cellular stress response pathway. The kinase is activated in response to hypotonic stress, leading to phosphorylation of several cation-chloride-coupled cotransporters. The catalytically active kinase specifically activates the p38 MAP kinase pathway, and its interaction with p38 decreases upon cellular stress, suggesting that this kinase may serve as an intermediate in the response to cellular stress.
Gewebespezifität
Predominantly expressed in brain and pancreas followed by heart, lung, kidney, skeletal muscle, liver, placenta and testis.
Sequenzähnlichkeiten
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
Posttranslationale Modifikation
Phosphorylated at Ser-309 by PRKCQ (PubMed:14988727). Autophosphorylation at Thr-231 positively regulates its activity (By similarity).
Zellort
Cytoplasm. Nucleus.
Nucleus when caspase-cleaved.
