Synaptophysin ist ein Gen, das durch das Symbol SYP kodiert wird. Es ist auch bekannt als: Major synaptic vesicle protein p38; SYP. Synaptophysin hat eine Masse von 33.85kDa, eine Aminosäurelänge von 313, und ist an Mental retardation, X-linked 96 beteiligt.
Wir bieten 38 antikörper gegen Synaptophysin, aufgewachsen in Kaninchen und Maus, welche geeignet sind für WB, IHC, ELISA, ICC/IF, IP and ChIP mit Proben abgeleitet von Human, Maus, Ratte, Rind, Affe, Huhn und Hamster.
Gen- und Proteininformationen
UniProt Zusammenfassung
Possibly involved in structural functions as organizing other membrane components or in targeting the vesicles to the plasma membrane. Involved in the regulation of short-term and long-term synaptic plasticity (By similarity).
Entrez Zusammenfassung
This gene encodes an integral membrane protein of small synaptic vesicles in brain and endocrine cells. The protein also binds cholesterol and is thought to direct targeting of vesicle-associated membrane protein 2 (synaptobrevin) to intracellular compartments. Mutations in this gene are associated with an X-linked form of cognitive disability.
Gewebespezifität
Expressed in the brain, with expression in the hippocampus, the neuropil in the dentate gyrus, where expression is higher in the outer half of the molecular layer than in the inner half, and in the neuropil of CA4 and CA3.
Rolle bei Krankheiten
Mental retardation, X-linked 96: A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period.
Sequenzähnlichkeiten
Belongs to the synaptophysin/synaptobrevin family.
Posttranslationale Modifikation
Ubiquitinated; mediated by SIAH1 or SIAH2 and leading to its subsequent proteasomal degradation.
Zellort
Cytoplasmic vesicle > Secretory vesicle > Synaptic vesicle membrane. Cell junction > Synapse > Synaptosome.
