TNFSF9 ist ein Gen, das durch das Symbol TNFSF9 kodiert wird. Es ist auch bekannt als: Tumor necrosis factor ligand superfamily member 9; 4-1BB ligand; 4-1BBL. TNFSF9 hat eine Masse von 26.63kDa und eine Aminosäurelänge von 254.
Wir bieten 13 antikörper gegen TNFSF9, aufgewachsen in Kaninchen, Maus und Ratte, welche geeignet sind für WB, IHC, ELISA, ICC/IF, FC and IP mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
Cytokine that binds to TNFRSF9. Induces the proliferation of activated peripheral blood T-cells. May have a role in activation-induced cell death (AICD). May play a role in cognate interactions between T-cells and B-cells/macrophages.
Entrez Zusammenfassung
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This transmembrane cytokine is a bidirectional signal transducer that acts as a ligand for TNFRSF9/4-1BB, which is a costimulatory receptor molecule in T lymphocytes. This cytokine and its receptor are involved in the antigen presentation process and in the generation of cytotoxic T cells. The receptor TNFRSF9/4-1BB is absent from resting T lymphocytes but rapidly expressed upon antigenic stimulation. The ligand encoded by this gene, TNFSF9/4-1BBL, has been shown to reactivate anergic T lymphocytes in addition to promoting T lymphocyte proliferation. This cytokine has also been shown to be required for the optimal CD8 responses in CD8 T cells. This cytokine is expressed in carcinoma cell lines, and is thought to be involved in T cell-tumor cell interaction.
Gewebespezifität
Expressed in brain, placenta, lung, skeletal muscle and kidney.
Sequenzähnlichkeiten
Belongs to the tumor necrosis factor family.
