ULBP1 ist ein Gen, das durch das Symbol ULBP1 kodiert wird. Es ist auch bekannt als: UL16-binding protein 1; ALCAN-beta; NKG2D ligand 1; N2DL-1; Retinoic acid early transcript 1I; N2DL1; RAET1I. ULBP1 hat eine Masse von 28kDa und eine Aminosäurelänge von 244.
Wir bieten 3 antikörper gegen ULBP1, aufgewachsen in Kaninchen, welche geeignet sind für WB and IHC mit Proben abgeleitet von Human und Maus.
Gen- und Proteininformationen
UniProt Zusammenfassung
Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity.
Entrez Zusammenfassung
The protein encoded by this gene is a ligand of natural killer group 2, member D (NKG2D), an immune system-activating receptor on NK cells and T-cells. Binding of the encoded ligand to NKG2D leads to activation of several signal transduction pathways, including those of JAK2, STAT5, ERK and PI3K kinase/Akt. Also, in cytomegalovirus-infected cells, this ligand binds the UL16 glycoprotein and is prevented from activating the immune system. Three transcript variants encoding different isoforms have been found for this gene.
Gewebespezifität
Expressed in T-cells, B-cells, erythroleukemia cell lines and in a wide range of tissues including heart, brain, lung, liver, testis, lymph node, thymus, tonsil and bone marrow. Also found in fetal heart, brain, lung and liver.
Sequenzähnlichkeiten
Belongs to the MHC class I family.
Zellort
Cell membrane. Endoplasmic reticulum.
In CMV-infected fibroblasts, detected in the endoplasmic reticulum/cis-Golgi.
