VDAC3 ist ein Gen, das durch das Symbol VDAC3 kodiert wird. Es ist auch bekannt als: Voltage-dependent anion-selective channel protein 3; VDAC-3; Outer mitochondrial membrane protein porin 3. VDAC3 hat eine Masse von 30.66kDa und eine Aminosäurelänge von 283.
Wir bieten 2 antikörper gegen VDAC3, aufgewachsen in Kaninchen, welche geeignet sind für WB, IHC and ICC/IF mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules.
Entrez Zusammenfassung
This gene encodes a voltage-dependent anion channel (VDAC), and belongs to the mitochondrial porin family. VDACs are small, integral membrane proteins that traverse the outer mitochondrial membrane and conduct ATP and other small metabolites. They are known to bind several kinases of intermediary metabolism, thought to be involved in translocation of adenine nucleotides, and are hypothesized to form part of the mitochondrial permeability transition pore, which results in the release of cytochrome c at the onset of apoptotic cell death. Alternatively transcript variants encoding different isoforms have been described for this gene.
Gewebespezifität
Widely expressed. Highest in testis.
Sequenzähnlichkeiten
Belongs to the eukaryotic mitochondrial porin family.
Posttranslationale Modifikation
Ubiquitinated by PRKN during mitophagy, leading to its degradation and enhancement of mitophagy. Deubiquitinated by USP30.
Zellort
Mitochondrion outer membrane.
