VMAT2 ist ein Gen, das durch das Symbol SLC18A2 kodiert wird. Es ist auch bekannt als: Synaptic vesicular amine transporter; Monoamine transporter; Solute carrier family 18 member 2; Vesicular amine transporter 2; VAT2; SLC18A2; SVMT. VMAT2 hat eine Masse von 55.71kDa, eine Aminosäurelänge von 514, und ist an Parkinsonism-dystonia, infantile, 2 beteiligt.
Wir bieten 10 antikörper gegen VMAT2, aufgewachsen in Kaninchen, Maus und Ziege, welche geeignet sind für WB, IHC, ELISA, ICC/IF and FC mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
Involved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters. Pumps cytosolic monoamines including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles (PubMed:23363473). Requisite for vesicular amine storage prior to secretion via exocytosis.
Entrez Zusammenfassung
The vesicular monoamine transporter acts to accumulate cytosolic monoamines into synaptic vesicles, using the proton gradient maintained across the synaptic vesicular membrane. Its proper function is essential to the correct activity of the monoaminergic systems that have been implicated in several human neuropsychiatric disorders. The transporter is a site of action of important drugs, including reserpine and tetrabenazine (summary by Peter et al., 1993
Rolle bei Krankheiten
Parkinsonism-dystonia, infantile, 2: An autosomal recessive disorder characterized by infantile onset of abnormal movements, including parkinsonism, dystonia, and poor fine motor skills, as well as autonomic dysfunction, including abnormal sweating, cold extremities, and poor sleep. Some patients have variable degrees of developmental delay.
Sequenzähnlichkeiten
Belongs to the major facilitator superfamily. Vesicular transporter family.
Zellort
Cytoplasmic vesicle membrane.
