CCL28 ist ein Gen, das durch das Symbol CCL28 kodiert wird. Andere Namen sind: C-C motif chemokine 28; Mucosae-associated epithelial chemokine; MEC; Protein CCK1; Small-inducible cytokine A28; SCYA28. CCL28 hat eine Masse von 14.28kDa und eine Aminosäurelänge von 127.
Wir bieten 4 CCL28proteine an
Gen- und Proteininformationen
UniProt Zusammenfassung
Chemotactic activity for resting CD4, CD8 T-cells and eosinophils. Binds to CCR3 and CCR10 and induces calcium mobilization in a dose-dependent manner.
Entrez Zusammenfassung
This antimicrobial gene belongs to the subfamily of small cytokine CC genes. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for resting CD4 or CD8 T cells and eosinophils. The product of this gene binds to chemokine receptors CCR3 and CCR10. This chemokine may play a role in the physiology of extracutaneous epithelial tissues, including diverse mucosal organs. Multiple transcript variants encoding two different isoforms have been found for this gene.
Gewebespezifität
Preferentially expressed by epithelial cells of diverse tissues including normal and pathological colon, salivary gland, mammary gland, trachea and rectum. Also found in prostate, spleen, thyroid, psoriasis skin and in lower levels in peripheral blood leukocytes, small intestine, Peyer patches, stomach and normal skin.
Sequenzähnlichkeiten
Belongs to the intercrine beta (chemokine CC) family.
