CD73 ist ein Gen, das durch das Symbol NT5E kodiert wird. Andere Namen sind: 5'-nucleotidase; 5'-NT; Ecto-5'-nucleotidase; NT5E; NT5; NTE. CD73 hat eine Masse von 63.37kDa, eine Aminosäurelänge von 574, und ist an Calcification of joints and arteries beteiligt.
Wir bieten 4 CD73proteine an
Gen- und Proteininformationen
UniProt Zusammenfassung
Hydrolyzes extracellular nucleotides into membrane permeable nucleosides. Exhibits AMP-, NAD-, and NMN-nucleosidase activities.
Entrez Zusammenfassung
The protein encoded by this gene is a plasma membrane protein that catalyzes the conversion of extracellular nucleotides to membrane-permeable nucleosides. The encoded protein is used as a determinant of lymphocyte differentiation. Defects in this gene can lead to the calcification of joints and arteries. Two transcript variants encoding different isoforms have been found for this gene.
Rolle bei Krankheiten
Calcification of joints and arteries: A condition characterized by adult-onset calcification of the lower extremity arteries, including the iliac, femoral and tibial arteries, and hand and foot capsule joints. Age of onset has been reported as early as the second decade of life, usually involving intense joint pain or calcification in the hands.
Sequenzähnlichkeiten
Belongs to the 5'-nucleotidase family.
