CD99 ist ein Gen, das durch das Symbol CD99 kodiert wird. Andere Namen sind: CD99 antigen; 12E7; E2 antigen; Protein MIC2; T-cell surface glycoprotein E2; MIC2; MIC2X; MIC2Y. CD99 hat eine Masse von 18.85kDa und eine Aminosäurelänge von 185.
Wir bieten 4 CD99proteine an
Gen- und Proteininformationen
UniProt Zusammenfassung
Involved in T-cell adhesion processes and in spontaneous rosette formation with erythrocytes. Plays a role in a late step of leukocyte extravasation helping leukocytes to overcome the endothelial basement membrane. Acts at the same site as, but independently of, PECAM1. Involved in T-cell adhesion processes (By similarity).
Entrez Zusammenfassung
The protein encoded by this gene is a cell surface glycoprotein involved in leukocyte migration, T-cell adhesion, ganglioside GM1 and transmembrane protein transport, and T-cell death by a caspase-independent pathway. In addition, the encoded protein may have the ability to rearrange the actin cytoskeleton and may also act as an oncosuppressor in osteosarcoma. This gene is found in the pseudoautosomal region of chromosomes X and Y and escapes X-chromosome inactivation. There is a related pseudogene located immediately adjacent to this locus.
Sequenzähnlichkeiten
Belongs to the CD99 family.
Posttranslationale Modifikation
Extensively O-glycosylated.
