CTGF ist ein Gen, das durch das Symbol CCN2 kodiert wird. Andere Namen sind: CCN family member 2; Cellular communication network factor 2; Connective tissue growth factor; Hypertrophic chondrocyte-specific protein 24; Insulin-like growth factor-binding protein 8; IBP-8; CCN2; HCS24; IGFBP8. CTGF hat eine Masse von 38.09kDa und eine Aminosäurelänge von 349.
Wir bieten 6 CTGFproteine an
Gen- und Proteininformationen
UniProt Zusammenfassung
Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes. Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells. Enhances fibroblast growth factor-induced DNA synthesis.
Entrez Zusammenfassung
The protein encoded by this gene is a mitogen that is secreted by vascular endothelial cells. The encoded protein plays a role in chondrocyte proliferation and differentiation, cell adhesion in many cell types, and is related to platelet-derived growth factor. Certain polymorphisms in this gene have been linked with a higher incidence of systemic sclerosis.
Gewebespezifität
Expressed in bone marrow and thymic cells. Also expressed one of two Wilms tumors tested.
Sequenzähnlichkeiten
Belongs to the CCN family.
Zellort
Secreted > Extracellular space > Extracellular matrix. Secreted.
