Enterokinase ist ein Gen, das durch das Symbol TMPRSS15 kodiert wird. Andere Namen sind: Enteropeptidase; Serine protease 7; Transmembrane protease serine 15; TMPRSS15; ENTK; PRSS7. Enterokinase hat eine Masse von 112.94kDa, eine Aminosäurelänge von 1019, und ist an Enterokinase deficiency beteiligt.
Wir bieten 3 Enterokinaseproteine an
Gen- und Proteininformationen
UniProt Zusammenfassung
Responsible for initiating activation of pancreatic proteolytic proenzymes (trypsin, chymotrypsin and carboxypeptidase A). It catalyzes the conversion of trypsinogen to trypsin which in turn activates other proenzymes including chymotrypsinogen, procarboxypeptidases, and proelastases.
Entrez Zusammenfassung
This gene encodes an enzyme that converts the pancreatic proenzyme trypsinogen to trypsin, which activates other proenzymes including chymotrypsinogen and procarboxypeptidases. The precursor protein is cleaved into two chains that form a heterodimer linked by a disulfide bond. This protein is a member of the trypsin family of peptidases. Mutations in this gene cause enterokinase deficiency, a malabsorption disorder characterized by diarrhea and failure to thrive.
Gewebespezifität
Intestinal brush border.
Rolle bei Krankheiten
Enterokinase deficiency: Life-threatening intestinal malabsorption disorder characterized by diarrhea and failure to thrive.
Sequenzähnlichkeiten
Belongs to the peptidase S1 family.
Posttranslationale Modifikation
The chains are derived from a single precursor that is cleaved by a trypsin-like protease.
