EREG ist ein Gen, das durch das Symbol EREG kodiert wird. Es ist auch bekannt als Proepiregulin. EREG hat eine Masse von 19.04kDa und eine Aminosäurelänge von 169.
Wir bieten 3 EREGproteine an
Gen- und Proteininformationen
UniProt Zusammenfassung
Ligand of the EGF receptor/EGFR and ERBB4. Stimulates EGFR and ERBB4 tyrosine phosphorylation (PubMed:9419975). Contributes to inflammation, wound healing, tissue repair, and oocyte maturation by regulating angiogenesis and vascular remodeling and by stimulating cell proliferation (PubMed:24631357).
Entrez Zusammenfassung
This gene encodes a secreted peptide hormone and member of the epidermal growth factor (EGF) family of proteins. The encoded protein is a ligand of the epidermal growth factor receptor (EGFR) and the structurally related erb-b2 receptor tyrosine kinase 4 (ERBB4). The encoded protein may be involved in a wide range of biological processes including inflammation, wound healing, oocyte maturation, and cell proliferation. Additionally, the encoded protein may promote the progression of cancers of various human tissues.
Gewebespezifität
In normal adults, expressed predominantly in the placenta and peripheral blood leukocytes. High levels were detected in carcinomas of the bladder, lung, kidney and colon.
Zellort
Secreted > Extracellular space.
