GFR alpha 3 ist ein Gen, das durch das Symbol GFRA3 kodiert wird. Im Allgemeinen auch bezeichnet als: GDNF family receptor alpha-3; GDNF receptor alpha-3; GFRA3. GFR alpha 3 hat eine Masse von 44.51kDa und eine Aminosäurelänge von 400.
Wir bieten 1 GFR alpha 3proteine an
Gen- und Proteininformationen
UniProt Zusammenfassung
Receptor for the glial cell line-derived neurotrophic factor, ARTN (artemin). Mediates the artemin-induced autophosphorylation and activation of the RET receptor tyrosine kinase.
Entrez Zusammenfassung
The protein encoded by this gene is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor and a member of the GDNF receptor family. It forms a signaling receptor complex with RET tyrosine kinase receptor and binds the ligand, artemin.
Gewebespezifität
Widely expressed in adult and fetus which exhibit a similar pattern. Essentially not expressed in the central nervous system, but highly expressed in several sensory and sympathetic ganglia of the peripheral nervous system. Moderate expression in many non-neuronal tissues, particularly those of the digestive and urogenital systems, but high expression in stomach and appendix. Several types of glandular tissues show low expression. Very low or no expression detected in the hematopoietic system.
Sequenzähnlichkeiten
Belongs to the GDNFR family.
Posttranslationale Modifikation
N-glycosylated.
