HDGF ist ein Gen, das durch das Symbol HDGF kodiert wird. Im Allgemeinen auch bezeichnet als: Hepatoma-derived growth factor; High mobility group protein 1-like 2; HMG-1L2; HMG1L2. HDGF hat eine Masse von 26.79kDa und eine Aminosäurelänge von 240.
Wir bieten 1 HDGFproteine an
Gen- und Proteininformationen
UniProt Zusammenfassung
Acts as a transcriptional repressor (PubMed:17974029). Has mitogenic activity for fibroblasts (PubMed:11751870, PubMed:26845719). Heparin-binding protein (PubMed:15491618).
Entrez Zusammenfassung
This gene encodes a member of the hepatoma-derived growth factor family. The encoded protein has mitogenic and DNA-binding activity and may play a role in cellular proliferation and differentiation. High levels of expression of this gene enhance the growth of many tumors. This gene was thought initially to be located on chromosome X; however, that location has been determined to correspond to a related pseudogene. Alternatively spliced transcript variants encoding distinct isoforms have been described.
Gewebespezifität
Ubiquitous.
Sequenzähnlichkeiten
Belongs to the HDGF family.
Posttranslationale Modifikation
Sumoylated with SUMO1. Sumoylation prevents binding to chromatin.
Zellort
Nucleus. Cytoplasm. Secreted > Extracellular exosome.
Secreted by exosomes and is located inside the exosome (PubMed:27926477). May also be secreted as free protein via an as yet unknown pathway (PubMed:27926477).
