LACTB ist ein Gen, das durch das Symbol LACTB kodiert wird. Im Allgemeinen auch bezeichnet als: Serine beta-lactamase-like protein LACTB, mitochondrial; MRPL56. LACTB hat eine Masse von 60.69kDa und eine Aminosäurelänge von 547.
Wir bieten 2 LACTBproteine an
Gen- und Proteininformationen
UniProt Zusammenfassung
Mitochondrial serine protease that acts as a regulator of mitochondrial lipid metabolism (PubMed:28329758). Acts by decreasing protein levels of PISD, a mitochondrial enzyme that converts phosphatidylserine (PtdSer) to phosphatidylethanolamine (PtdEtn), thereby affecting mitochondrial lipid metabolism (PubMed:28329758). It is unclear whether it acts directly by mediating proteolysis of PISD or by mediating proteolysis of another lipid metabolism protein (PubMed:28329758). Acts as a tumor suppressor that has the ability to inhibit proliferation of multiple types of breast cancer cells: probably by promoting decreased levels of PISD, thereby affecting mitochondrial lipid metabolism (PubMed:28329758).
Entrez Zusammenfassung
This gene encodes a mitochondrially-localized protein that has sequence similarity to prokaryotic beta-lactamases. Many of the residues responsible for beta-lactamase activity are not conserved in this protein, suggesting it may have a different enzymatic function. Increased expression of the related mouse gene was found to be associated with obesity. Alternative splicing results in multiple transcript variants encoding different protein isoforms.
Gewebespezifität
Expressed predominantly in skeletal muscle.
Sequenzähnlichkeiten
Belongs to the peptidase S12 family.
