LIF ist ein Gen, das durch das Symbol LIF kodiert wird. Im Allgemeinen auch bezeichnet als: Leukemia inhibitory factor; Differentiation-stimulating factor; D factor; Melanoma-derived LPL inhibitor; MLPLI; HILDA. LIF hat eine Masse von 22.01kDa und eine Aminosäurelänge von 202.
Wir bieten 6 LIFproteine an
Gen- und Proteininformationen
UniProt Zusammenfassung
LIF has the capacity to induce terminal differentiation in leukemic cells. Its activities include the induction of hematopoietic differentiation in normal and myeloid leukemia cells, the induction of neuronal cell differentiation, and the stimulation of acute-phase protein synthesis in hepatocytes.
Entrez Zusammenfassung
The protein encoded by this gene is a pleiotropic cytokine with roles in several different systems. It is involved in the induction of hematopoietic differentiation in normal and myeloid leukemia cells, induction of neuronal cell differentiation, regulator of mesenchymal to epithelial conversion during kidney development, and may also have a role in immune tolerance at the maternal-fetal interface. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Sequenzähnlichkeiten
Belongs to the LIF/OSM family.
