Lymphotactin ist ein Gen, das durch das Symbol XCL1 kodiert wird. Im Allgemeinen auch bezeichnet als: ATAC; C motif chemokine 1; Cytokine SCM-1; Lymphotaxin; SCM-1-alpha; Small-inducible cytokine C1; XC chemokine ligand 1; XCL1; LTN; SCYC1. Lymphotactin hat eine Masse von 12.52kDa und eine Aminosäurelänge von 114.
Wir bieten 2 Lymphotactinproteine an
Gen- und Proteininformationen
UniProt Zusammenfassung
Chemotactic activity for lymphocytes but not for monocytes or neutrophils. In thymus, mediates medullary accumulation of thymic dendritic cells and contributes to regulatoy T cell development, playing a role in self-tolerance establishment.
Entrez Zusammenfassung
This antimicrobial gene encodes a member of the chemokine superfamily. Chemokines function in inflammatory and immunological responses, inducing leukocyte migration and activation. The encoded protein is a member of the C-chemokine subfamily, retaining only two of four cysteines conserved in other chemokines, and is thought to be specifically chemotactic for T cells. This gene and a closely related family member are located on the long arm of chromosome 1.
Gewebespezifität
Highest level in spleen, lower in peripheral leukocytes and very low levels in lung, colon and small intestine.
Sequenzähnlichkeiten
Belongs to the intercrine gamma family.
